Normative Data of Brain Network Activation in Adolescents and Young Adults

Establishment of Normative Data of Brain Network Activation (BNA) Using Evoked Response Potentials in Adolescents and Young Adults

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01460394

Enrollment

Registered

2011-10-26

Start date

2011-10-31

Completion date

2012-04-30

Last updated

2019-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Controls

Keywords

Healthy, Control

Brief summary

Establish normative data of ElMindA's Brain Network Activation (BNA) using evoked response in two age groups: adolescents and young adults.

Detailed description

Currently, there is no reliable, practical, and non-invasive method for assessing changes in electrophysiological activity of the brain associated with brain-related pathologies, e.g., concussion, ADHD, autistic spectrum disorders (ASD), etc. Event Related Potentials (ERPs), which are temporal reflections of the neural mass electrical activity of cells in specific regions of the brain that occur in response to stimuli, may offer such a method, as they provide both a noninvasive and portable measure of brain function. The ERPs provide excellent temporal information, but spatial resolution for ERPs has traditionally been limited. However, by using high-density electroencephalograph (EEG) recording spatial resolution for ERPs is improved significantly. The paradigm for the current study will combine neurophysiological knowledge with mathematical signal processing and pattern recognition methods (BNA) to temporally and spatially map brain function, connectivity and synchronization. The need of objective measures that will help the clinician in its decision making in brain-related pathologies is recognized. BNA is a new imaging modality that has been developed to fill this gap.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

15 Years to 24 Years

Healthy volunteers

Yes

Inclusion criteria

* Age 15-24 years. * Willingness to participate and able to give informed assent (child) and/or consent (parent for minors or adult 18+ years of age for self).

Exclusion criteria

* Currently participate in a contact sport (e.g., football, hockey, soccer, rugby, lacrosse, martial arts). * Currently with lice, open wounds on scalp. * Any chronic disease. * Any psychiatric disorder, e.g., depression, bipolar disorder, schizophrenic disorder, etc. * Any CNS neurologic disorder, e.g., epilepsy, seizures, etc. * Any neuropsychological disorders, e.g.: ADHD, Autistic Spectrum Disorder (ASD), etc. * History of Special education, e.g., reading disorder (dyslexia), writing disorder (dysgraphia), math disorder (dyscalculia), nonverbal learning disorder. * History of any medication affecting CNS within the last 3 months, e.g., antidepressants, anticonvulsants, psychostimulants, first generation antihistamines, etc. * Substance abuse in the last 3 months. * Significant sensory deficits, e.g., deafness or blindness. * History of any brain trauma.

Design outcomes

Primary

Measure	Time frame	Description
Functional networks of brain activity in healthy individuals measured using analysis of EEG Event Related Potential (ERP) data	1 week	The study outcome measure are functional networks of brain activity of healthy adolescents (age 15-18 years) and young adults (19-24 years) established based on an analysis of EEG data recorded while study subjects perform ERP tasks

Countries

United States

Outcome results