Cerebral Desaturation
Conditions
Keywords
cerebral oxymetry, systemic oxymetry, hepatic surgery, liver transplantation
Brief summary
The purpose of this study is to determine the clinical impact of cerebral and systemic desaturation during liver transplantation and resection on post-operative complications.
Detailed description
This is an observational study. Cerebral and systemic oxymetry (rSO2) using near infrared spectroscopy (NIRS, Invos 5100; Somanet- ics Corporation, Troy, MI) will be performed on all patients with 4 optodes (right and left temporal area, arm and leg). Continuous rSO2 values will be stored on a hard disk with a 15 seconds update within intraoperative period and first 4 hours after the surgery. Desaturation phases (saturation decrease more than 20% of the basal value for more than 15 seconds) will be correlated to operative procedure or events. Postoperative adverse events will be collected. A correlation between desaturation and postoperative adverse events will be done with a multiple linear regression model.
Interventions
OTHERsystemic and cerebral oxymetry
oxymetry measurement using near infrared spectroscopy
Sponsors
Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Medtronic - MITG
Centre hospitalier de l'Université de Montréal (CHUM)
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients undergoing an hepatic resection or hepatic transplantation * patients able to give consent with knowledge of french or english language.
Exclusion criteria
* age\< 18 years * patients with cerebral diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| define the correlation coefficient between the number of systemic and/or cerebral desaturation phases and the number of postoperative adverse events | from the beginning of anesthesia till 4 hours after the end of the surgery |
Secondary
| Measure | Time frame |
|---|---|
| define the prevalence of systemic and cerebral desaturation phases during hepatic surgery or transplantation | from the beginning of anesthesia till 4 hours after the end of the surgery |
| define the correlation coefficient between systemic and/or cerebral desaturation phases and the length of stay in intensive care unit | duration of intensive care stay, an expected average of 4 days |
| validate the equivalence of the systemic and cerebral oxymetry | from the beginning of anesthesia till 4 hours after the end of the surgery |
Countries
Canada
Outcome results
None listed