Matrix Metalloproteinases in Atherosclerosis of Chronic Kidney Disease

The Role of Matrix Metalloproteinases -2 and -9 in Atherosclerosis of Patients With Chronic Kidney Disease

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01458158

Acronym

MMACKD

Enrollment

300

Registered

2011-10-24

Start date

2011-10-31

Completion date

2016-05-31

Last updated

2015-02-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic Nephropathy

Keywords

Gelatinases, kidney disease, diabetes mellitus type 2

Brief summary

The purpose of this study is to determine whether matrix metalloproteinases are associated with atherosclerosis in the different stages of chronic kidney disease.

Detailed description

The purpose of this study is to determine the correlation of matrix metalloproteinases and atherosclerosis of chronic kidney disease. Patients with diabetes mellitus type 2,as a non-inflammatory leading cause of end stage renal failure and patients with chronic glomerulonephritis and similar course of proteinuria,as an inflammatory leading cause of end stage renal failure are enrolled.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

50 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Chronic kidney disease * Diabetes mellitus type 2

Exclusion criteria

* Malignancy

Design outcomes

Primary

Measure	Time frame	Description
Association of matrix metalloproteinases with atherosclerosis in patients with chronic kidney disease	two years	Matrix metalloproteinases associated with atherosclerosis in chronic kidney disease;patients with diabetes mellitus type 2 and others with chronic glomerulonephritis.Serum levels of MMPs-2 and -9 are measured by an ELISA system.Intima Media Thickness(IMT) of carotid and femoral arteries is measured with a high resolution ultrasonography.

Secondary

Measure	Time frame	Description
Matrix metalloproteinases and atherosclerosis associated with pro-inflammatory and oxidative stress markers in chronic kidney disease	two years	Matrix metalloproteinases associated with atherosclerosis markers,pro-inflammatory markers and markers of oxidative stress in chronic kidney disease

Countries

Greece

Contacts

Primary ContactGrigorios G. Dimas

gregorydimas@yahoo.gr+0030 6972321534

Outcome results