Effectiveness of Triclosan Coated Sutures in Preventing Leg Wound Infection After Coronary Artery Bypass Surgery

Effectiveness of Triclosan Coated VICRYL\MONOCRYL Sutures in Preventing Leg Wound Infection Compared to POLYSORB\ BIOSYN Sutures in Patients After Coronary Bypass Surgery- a Randomized Controlled Trial

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01457859

Enrollment

410

Registered

2011-10-24

Start date

2011-10-31

Completion date

2013-10-31

Last updated

2011-10-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complication of Coronary Artery Bypass Graft, Surgical Wound Infection

Brief summary

The purpose of this study is to assess whether triclosan-coated sutures reduces wound infections compared to regular non-coated sutures, after saphenous vein harvesting in CABG patients.

Interventions

DRUGTriclosan

Triclosan coated surgical sewing threads (VICRYL+ and MONOCRYL+) applied for leg wound closure after CABG

OTHERConventional non-coated surgical sutures

Conventional non-coated surgical sewing threads (POLYSORB and BIOSYN) will be applied after CABG for leg wound closure

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 18 years of age or older with written informed consent * Male and female subjects * Subjects scheduled for an elective and urgent CABG surgery that includes saphenous vein harvesting.

Exclusion criteria

* Known allergy or intolerance to triclosan * Different surgical prophylactic antibiotic regimen than common in the department. * Continuous preoperative and predicted postoperative antibiotic treatment.

Design outcomes

Primary

Measure	Time frame	Description
leg wound infection	Up to 45 days postsurgery	Proportion of subjects with leg wound infection in research versus control group within 45 days of surgery according to CDC SSI criteria

Secondary

Measure	Time frame	Description
Antibiotics administration	Up to 45 days postsurgery	Amount of administered antibiotic for leg wound infection after surgery
Hospital Length of stay	Average of 7 days postsurgery	—
Incidence of hospital re-admission due to leg wound infection	Within 45 days postsurgery	—

Countries

Israel

Contacts

Primary ContactLiran Shani, MD

l_shani@rambam.health.gov.il

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026