Effect of Feeding Frequency on Glucose and Insulin Metabolism and Substrate Partitioning in Impaired Glucose Tolerant (IGT) Men

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01456754

Enrollment

Registered

2011-10-21

Start date

2010-12-31

Completion date

2011-11-30

Last updated

2011-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glucose Intolerance

Keywords

Insulin Metabolism, Glucose Metabolism, Substrate Partitioning, Muscle Biopsies, Feeding Frequency, Insulin

Brief summary

The purpose of this study is to determine the effect of feeding frequency on glucose and insulin metabolism and substrate partitioning in impaired glucose tolerant (IGT) men.

Interventions

DIETARY_SUPPLEMENTlow feeding frequency (3x)

3 meals a day

DIETARY_SUPPLEMENTHigh feeding frequency (14x)

14 meals a day

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* BMI: 20-35 kg/m2 * Gender: Male * Age: subjects has to be older than 18 and younger than 70 years old * Impaired Glucose Tolerant (IGT) = plasma glucose, two hours after consuming 75g glucose, appears to be superior to 7.8mmol/l (normal level) but remains inferior to 11.1mmol/l (diabetes level) and fasting plasma glucose is less than 7.0mmol/l. * Caucasian

Exclusion criteria

1. Lactose intolerant 2. Diabetes Mellitus 3. Cardiovascular diseases 4. Stomach and intestinal diseases 5. Normal glucose levels after 2 hours 6. Anticoagulants 7. Medication that has a effect on energy and glucose homeostasis and absorption of foods 8. Conditions or situations when subjects can't lose 500 ml blood

Design outcomes

Primary

Measure	Time frame
Glucose metabolism	24 hour profile
Insulin metabolism	24 hour profile

Secondary

Measure	Time frame
Change in substrate partitioning (fat, carbohydrate and protein oxidation) between the two intervention diets	24 hour profiles
Metabolic markers (FFA and TG metabolism)	24 hour profile

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026