Gastric and Intestinal Satiation in Obese and Normal Weight Healthy People

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01456572

Enrollment

Registered

2011-10-20

Start date

2007-01-31

Completion date

2011-07-31

Last updated

2011-10-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endocrine System Diseases

Keywords

glucagon-like peptide-1, peptide tyrosine tyrosine, ghrelin, stomach, small intestine, gastric emptying

Brief summary

The purpose of this study is to determine the reciprocal control between gastric functions and intestinal parameters in the development of satiation in obese people.

Detailed description

Obesity has reached pandemic proportions, obesity-associated complications are extensive and the current treatment options are limited. These facts demonstrate the need for an improved understanding of the pathogenesis of obesity. The gastrointestinal tract plays a key element in the control of satiation; discrepancies exist, however, for the role of gastric and intestinal parameters in the control of satiation in relation to body mass. To achieve a comprehensive understanding for the reciprocal control between gastric functions and intestinal parameters in the development of satiation in obese people the investigators will compare satiation parameters, gastric emptying and plasma glucagon-like peptide-1 (GLP-1), peptide tyrosine tyrosine (PYY) and ghrelin levels between normal and obese healthy volunteers. Time needed to reach the level of satiation and total calorie intake will be measured by a standardized nutrient drink test; gastric emptying of solids by a 13C-octanoic acid breath test; and plasma GLP-1, PYY and ghrelin levels will be measured after a standardized nutrient drink.

Interventions

DIETARY_SUPPLEMENTensure plus

17 % protein, 30 % fat and 53 % carbohydrate; 1 kcal/mL

DIETARY_SUPPLEMENTstandardized test meal

scrambled eggs, two slices of whole wheat bread, 200 mL of milk and labeled with 13C-octanoic acid

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy subjects * age 18-45

Exclusion criteria

* smoking * substance abuse * regular intake of medication * medical or psychiatric illness * gastrointestinal disorders or food allergies

Design outcomes

Primary

Measure	Time frame
gastrointestinal peptide secretion	2 hours blood sampling

Secondary

Measure	Time frame
gastric emptying	240 minutes end-expiratory breath sample collection
time needed to reach the level of satiation	up to 30 min
total calorie intake	up to 30 min

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026