Heart Rate Variability of Patients With Bipolar Disorder in Subsyndromal Depressive Phase

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01455038

Enrollment

Registered

2011-10-19

Start date

2010-01-31

Completion date

2010-04-30

Last updated

2011-10-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bipolar Disorder, Heart Rate Variability, Subsyndromal Depressive Phase

Brief summary

The purposes of this study were: (1) to compare heart rate variability between bipolar patients in subsyndromal depressive phase and healthy controls (2) to evaluate the relation between the severity of subsyndromal depressive symptoms and reduced heart rate variability.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

1. Bipolar group: * DSM-IV bipolar disorder * Montgomery-Åsberg depression rating scale (MADRS) score for last one month : ≤ 10 * Clinical Global Impression severity (CGI-S) for last one month : ≤ 3 2. Healthy controls group: Subjects had no history of psychiatric disorder and had no psychiatric symptom when interviewed by a board-certified psychiatrist.

Exclusion criteria

* Psychiatric disorder except bipolar disorder * Neurological symptoms or signs * History of head trauma * History of cardiovascular diseases * Any medication except psychiatric medication.

Design outcomes

Primary

Measure	Time frame	Description
Heart rate variability (HRV)	at baseline	Time domain - NN (normal-to-normal R-R interval), HRV index (total number of all NN/ the height of the histogram of all NN), SDNN (standard deviation of the NN), RMSSD (the root mean square of differences of successive NN), NN50 (Number of pairs of adjacent NN intervals differing by more than 50 ms in the entire recording) and pNN50(NN50/total number of all NN). Frequency domain - TP (The variance of NN intervals over the temporal segment), VLF(Power in very low frequency range; \<0.04 Hz), LF(Power in low frequency range; 0.04\ 0.15 Hz), HF(Power in high frequency range; 0.15\ 0.4 Hz)

Countries

South Korea

Outcome results