Effects of Exercise-intensity on Physiological Adaptations in Overweight and Obese

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01453972

Acronym

TRENO

Enrollment

Registered

2011-10-18

Start date

2011-10-31

Completion date

2012-12-31

Last updated

2016-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, Overweight

Keywords

Exercise, High-intensity, Interval training

Brief summary

The main purpose of our study is to examine the physiological adaptations in oxygen transport chain for high-intensity exercise and moderate exercise in overweight and obese humans. The main goals are: 1. To investigate the most effective short-and long-interval training in terms of VO2max, pulmonary diffusion, cardiac output, endothelial function and mitochondrial function. 2. How these physiological adaptations affect the aerobic endurance and performance, and how this training can reduce the risk of cardiovascular diseases related to overweight and obesity.

Interventions

BEHAVIORALLong distanse moderate training

Moderate exercise

BEHAVIORALLong interval training

High-intensity exercise, long duration

BEHAVIORALShort interval training

High intensity exercise, short duration

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI \> 25

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
Maximal oxygen uptake	6 weeks	Change in maximal oxygen uptake will be measured after six weeks of various exercise training and related to changes in blood volume, cardiac function, endothelial function and mitochondrial function.

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026