IgA Nephropathy
Conditions
Keywords
enough steroids, MCD, efficacy
Brief summary
This is a single center,prospective,no-controlled clinical trial
Detailed description
1. The complete remission of enough steroids as inducement therapy in adult minimal change disease-like IgA nephropathy patients 2. The safety of enough steroids as inducement therapy in adult minimal change disease-like IgA nephropathy patients
Interventions
daily single dose of 1mg/kg (maximum 80mg) or alternate day single dose of 2mg/kg (maximum 120mg),maintained for a minimum period of 6 weeks and maximum period of 12 weeks. After achieving complete remission., corticosteroids should be tapered slowly, 10mg every two weeks tapered to reach 0.15mg/kg/d, then 2.5mg every two to four weeks tapered to reach the minimum dosage 10mg/ alternate day
Sponsors
Nanjing University School of Medicine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Female or male patients aged between 18 to 65 years * Renal biopsy was used to diagnose IgA nephropathy * Patients with 24h proteinuria 3.5g and serum albumin concentration lower than 30g/L
Exclusion criteria
* Patients with serum creatinine ≥ 3 mg/dl or eGFR \< 30ml/min per 1.73 m2 * urine RBC \> 1 million/ml * Patients who have received treatment of enough steroids for more than 12 weeks * patients with secondary IgA * Patients who have impaired liver function,with ALT/GPT or AST/GOT twice more than the normal upper limit or who have active hepatitis * Patients with 2 type diabetes or obesity, whose BMI is more than 28kg/m2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24h urinary protein excretion | 3 months |
Secondary
| Measure | Time frame |
|---|---|
| remission rate | 3 months |
Countries
China
Outcome results
None listed