Efficacy of Pre-operative Oral Pregabalin in Ambulatory Inguinal Hernia Repair for Post Operative Pain

Status

UNKNOWN

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01450345

Enrollment

Registered

2011-10-12

Start date

2009-09-30

Completion date

2011-12-31

Last updated

2011-10-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inguinal Hernia, Postoperative Pain

Keywords

Clinical diagnosis of inguinal hernia, Patient undergo operation under daycare basis, ASA I-II, Written consent

Brief summary

The study carry out is to determine whether the use of oral pregabalin premedication to assess the analgesic efficacy, opiod sparing, adverse effect and clinical value in post-operative pain management.

Interventions

DRUGPregabalin

The patient under Group P will be serving with 150 mg of oral Pregabalin 1 to 2 hours prior to induction.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

12 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of inguinal hernia * Patient undergo operation under daycare basis * ASA I-II * Written consent

Exclusion criteria

* ASA \> II * Allergic reaction against gabapentin and/or pregabalin * History of recurrent hernia repair. * Patient who has taken analgesia prior to the surgery * Liver failure * Renal failure * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Study is constructed to determine whether the use of oral pregabalin premedication to assess the analgesic efficacy for post operative pain at Alert, 15, 30, 45, 60 and 120 min, Day 1, Day 2 and Day 3.	3 days	Efficacy: To compare the VAS score for pain after operation between the group at Alert, 15, 30, 45, 60 and 120 min, Day 1, Day 2 and Day 3.

Secondary

Measure	Time frame	Description
Opiod Sparing	3 days	Total amount of rescue medication requires
Side effect of medication	3 days	Severity of Post operative nausea and vomiting (PONV) graded with mild, moderare and severe(Vomiting) Side effect of medication includes headache, giddiness, visual disturbance, and difficulty in walking.

Countries

Malaysia

Contacts

Primary ContactCharngChee Toh, MBBS, MRCS

toh2c79@yahoo.com60193380337

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026