Safety and Efficacy of Carbon Dioxide Insufflation During Colonoscopy With Consecutive Esophagogastroduodenoscopy in Reduction of Abdominal Pain in Sedated Outpatients

Carbon Dioxide Insufflation During Colonoscopy With Consecutive EGD is Safe and Decreases Abdominal Pain in Sedated Outpatients: a Randomized, Double-blind, Controlled Trial

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01450202

Acronym

COCE

Enrollment

100

Registered

2011-10-12

Start date

2011-11-30

Completion date

2012-01-31

Last updated

2012-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Keywords

Carbon dioxide insufflation, Colonoscopy, Esophagogastroduodenoscopy, Bowel insufflation, Postprocedure pain, Pain Due to Certain Specified Procedures

Brief summary

Compared with performing each procedure individually, performing two combined procedures such as colonoscopy consecutive Esophagogastroduodenoscopy (EGD) cause more bowel gases, abdominal distension and post-procedure pain because of longer procedure time related to more bowel insufflated gas than one procedure. To the best of the investigators knowledge, there has been no randomized controlled trial of CO2 versus air for insufflations during combined two procedures, colonoscopy with consecutive EGD. And there are a few well randomized trials concerned CO2 insufflation in patients receiving sedation during colonoscopy. The aim of the present study was to evaluate the efficacy of CO2 in reducing post-procedural abdominal pain and distension during colonoscopy consecutive EGD and to confirm the safety of CO2 insufflation when it is used during procedure in sedated outpatients.

Interventions

OTHERbowel insufflation gas

air insufflation, during colonoscopy and esophagogastroduodenoscopy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* outpatients between the ages of 18 and 70 years who are scheduled for colonoscopy with consecutive EGD

Exclusion criteria

* age \< 18 or \> 70 years * pregnancy * breast feeding * chronic obstructive lung disease (COPD) * known CO2 retention and refusal to participate in the study

Design outcomes

Primary

Measure	Time frame	Description
post-procedural pain	3 months	The primary end point of the study was to assess post-procedural pain according to VAS scale

Secondary

Measure	Time frame	Description
abdominal distention	3 months	abdominal distention using measurement of patient waist circumferences
ETCO2	3 months	Measure ETCO2 using nasal cannula

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026