Human Immunodeficiency Virus
Conditions
Keywords
Human Immunodeficiency Virus, Microchimerism, Maternal-Fetal Exchange, Gestation, HiV-vertical transmission
Brief summary
The aim of this single centre study is to measure maternal CD4+ t-cells in HiV exposed Newborns after spontaneous birth in comparison to cesarean section. This may have an influence on the risk of vertical HiV transmission.
Detailed description
At birth maternal CD4+ t-cells from umbilical cord blood and placenta blood are measured by microchimerism-analysis. After 6 weeks the maternal CD4+ t-cells are measured in the blood of the babies blood. Additionally we look for HiV in maternal CD4+ t-cells.
Interventions
None listed
Sponsors
Johann Wolfgang Goethe University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Minutes to 10 Minutes
Healthy volunteers
No
Inclusion criteria
• HiV exposed Newborns with normal risk of HiV transmission.
Exclusion criteria
* HiV exposed Newborns wiht elevated or high risk of HiV transmission. * HiV exposed Newborns of mothers not full of age. * missing informed consent of at least the mother * Outborns * Asphyxia * Major congenital defects * Chromosomal anomalies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maternal CD4+ t-cells in HiV exposed Newborns | Six weeks after date of birth | The maternal CD4+ t-cells are measured by microchimersimanalysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Analysis of HiV in maternal CD4+ t-cells | 2 month after delivery | HiV-PCR analysis from maternal CD4+ cells |
| Measurement of maternal CD8+ t-cells in the Newborn | 6 weeks | Measurement of maternal CD8+ t-cells by microchimerismanalysis |
| HiV transmission rate | 6 month after birth | Measurement of HiV PCR at the age of 6 month after birth |
Countries
Germany
Outcome results
None listed