Metabolomic Embryo Profiles of Obese in Vitro Fertilization (IVF) Patients and Their Relationship With Polycystic Ovary Syndrome (PCO)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01448863

Enrollment

Registered

2011-10-07

Start date

2011-10-31

Completion date

2014-10-31

Last updated

2015-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility, Obesity

Brief summary

The present study aims to elucidate if there is a metabolomic profile alteration in the embryos of obese women in order to understand if the reduced implantation rate observed in these patients is directly related to this factor. Furthermore, the investigators seek to establish if there is any difference between obese women with Polycystic Ovary Syndrome (PCO) and without PCO. The investigators compare these metabolomic profile embryos with embryos of egg-donation programme.

Interventions

OTHERCulture medium metabolomic analysis

During the embryo transfer at day 3, the investigators keep and freeze a small drop of the culture medium of each embryo transferred. Each drop of culture medium will have a volume of 40-50 microliters, before freezing is spun at 10.000 rps to avoid any possible contamination. The frozen media culture is analyzed for the metabolomic profile.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 38 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI \> 30 kg/m2 * Age \< 38 years old * Non smokers * First IVF cycle (groups 2 & 3, not Control group) * Normal uterus (seen by ultrasound) * normal basal hormonal profile(FSH,LH,estradiol,testosterone,androstenedione, insulin, SHBG, glucose, AMH) * Antral follicle count(\> 5 FA for each ovary) * Menses every 25-35 days.

Exclusion criteria

* \< 5 or \> 20 oocytes retrieved after stimulation cycle * estradiol \>3000 pg/ml or progesterone \> 1,5 ng/ml on the hCG day. * \< 2 evolutive embryos in the culture medium.

Design outcomes

Primary

Measure	Time frame	Description
Metabolic profile of culture media of Day 3 embryos	3 days	Determine differences in the metabolomic profile of the culture media of day 3 embryos, obtained after in vitro fertilization, according to the presence of obesity associated or not with polycystic ovary syndrome.

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 4, 2026