Cluster Headache
Conditions
Keywords
Cluster Headache, Trigeminal Autonomic Cephalalgias, Sleep, Circadian Rhythms
Brief summary
The purpose of this study is to assess both the sleep and circadian (24-hourly biological rhythms) physiology of people with cluster headache. For sufferers with the episodic form of the disorder this will involve observation at two separate time points, once when experiencing attacks (in-bout) and once when attack free (out-of-bout). The study will include measurement of basic rest-activity patterns, sleep timing and timing of individual attacks, as well as a more detailed study recording sleep and circadian rhythms under clinical conditions over consecutive nights. Studying the differences in these processes in single individuals when they are both experiencing and free from attacks might provide insight into the brain mechanisms involved in triggering the bouts of attacks and individual attacks themselves. An improved understanding of this area may help design improved treatment options in future.
Interventions
OTHERPolysomnography
Overnight physiological recording of sleep
OTHERActigraphy
Wristwatch activity to measure basic rest activity cycle and sleep efficiency
Sponsors
University of California, San Francisco
University of Surrey
Study design
Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of cluster headache or closely related primary headache disorder
Exclusion criteria
* Abnormality on screening investigations that increase risk of participation * Alcohol consumption exceeding 21 units per week
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| amplitude and phase of circadian rhythm of melatonin | 36 hours |
Countries
United Kingdom
Outcome results
None listed