Deep Vein Thrombosis
Conditions
Keywords
Deep Vein Thrombosis, total hip arthroplasty, prophylactic anticoagulation, randomized study
Brief summary
Deep vein thrombosis (DVT) remains a life-threatening complication of arthroplasty. It remains controversial for anticoagulation strategies after total hip arthroplasty (THA). A randomized double-blind study was conducted to determine whether prophylactic anticoagulation was efficient reduce DVT after THA. subjects who underwent uncemented THA were assigned to prophylactic anticoagulation group or non- prophylactic anticoagulation group. Patients were followed up 3 months later after surgery. DVT was tested by contrast venography. Investigator also used logistic regression analysis with variable selection for obtaining the prediction model of DVT. DVT after THA was affected by personal (age) and clinical factors (mechanical compression, duration of surgery). THA with short duration of surgery did not require prophylactic anticoagulation.
Interventions
OTHERprophylactic anticoagulation
prophylactic anticoagulation by rivaroxaban
Sponsors
JIANG Qing
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
35 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Primary total hip arthroplasty
Exclusion criteria
* Revision hip replacement, total knee replacement, revision knee replacement, semi-hip replacement and cemented THR were excluded. * Coagulation related disease and cancer were excluded either.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| all cause DVT | 7 days | deep-vein thrombosis nonfatal pulmonary embolism, or death |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Major DVT | 7 days | major venous thromboembolism (proximal deep-vein thrombosis, nonfatal pulmonary embolism, or death from venous thromboembolism) |
Countries
China
Outcome results
None listed