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Motor Performance in Parkinson's Disease After High Intensive Exercise or Deep Brain Stimulation

Quantitative Modeling of Motor Performance in Parkinson's Disease After High Intensive Antigravity Locomotor Exercise or Deep Brain Stimulation

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01446549
Enrollment
40
Registered
2011-10-05
Start date
2010-07-31
Completion date
2013-09-30
Last updated
2013-09-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease

Brief summary

The purpose of this study is (1) to provide quantitative information of the motor manifestations of Parkinson's disease and (2) to quantify the effect of high intensive antigravity locomotor exercise or Deep Brain Stimulation implantations in Parkinson's disease.

Interventions

OTHERHigh intensive antigravity locomotor exercise

High intensive antigravity locomotor exercise, 3 sessions/week, for 8 weeks.

PROCEDUREDeep Brain Stimulation

Deep Brain Stimulation implantation

Sponsors

Hvidovre University Hospital
CollaboratorOTHER
Bispebjerg Hospital
CollaboratorOTHER
Danish Parkinson Association
CollaboratorOTHER
University of Copenhagen
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
MALE
Age
50 Years to 75 Years
Healthy volunteers
Yes

Inclusion criteria

(exercise arm): * Idiopathic Parkinson's disease * A stable condition the last 6 months * Hoehn and Yahr 2 - 3 Inclusion Criteria (Deep Brain Stimulation arm): * Patients referred to Deep Brain Stimulation

Exclusion criteria

* Cardiovascular disease * Conditions that contraindicate physical exercise or the examination

Design outcomes

Primary

MeasureTime frameDescription
Change in Isometric Tremor Approximate EntropyChange from baseline up to 16 weeksApproximate Entropy is a metric. When used to quantify isometric tremor irregularity, information of dominant/pathological CNS oscillators can be obtained.

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026