The Effect of Positive End Expiratory Pressure (PEEP) During Laparoscopic Cholecystectomy

The Effect of PEEP on Regional Cerebral Oxygen Saturation During Laparoscopic Cholecystectomy

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01443962

Acronym

lapaPEEP

Enrollment

Registered

2011-09-30

Start date

2011-11-30

Completion date

2012-03-31

Last updated

2013-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Ischemia

Keywords

laparoscopic cholecystectomy, PEEP, rSO2

Brief summary

During the laparoscopic cholecystectomy, Pneumoperitoneum could affect to the regional oxygen saturation of brain. positive end expiratory pressure (PEEP)could improve the respiratory parameters include oxygenation. So applying PEEP could improve the regional brain oxygen saturation (rSO2)

Detailed description

During the laparoscopic cholecystectomy, Pneumoperitoneum could affect to the regional oxygen saturation of brain due to increased intracranial pressure, central venous pressure and make worse to respiratory parameters. Positive end expiratory pressure could improve the respiratory parameters include oxygenation. So applying PEEP could improve the regional oxygen saturation of brain during the pneumoperitoneum during the laparoscopic cholecystectomy.

Interventions

OTHERPEEP

applying PEEP 0 cmH2O during pneumoperitoneum continuously

OTHERZEEP

applying PEEP 10 cmH2O during pneumoperitoneum continuously

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Inclusion criteria

* ASA I or II, * 20-65 year, * patient who undergoing laparoscopic cholecystectomy

Exclusion criteria

* cerebrovascular disease, * coronary artery disease, * morbid obesity (BMI \> 30) * propofol allergy, * addictive

Design outcomes

Primary

Measure	Time frame	Description
change in regional brain oxygen saturation	from baseline record rSO2 every 10 minutes	FiO2 0.6, Tidal vlume 8 ml/IBW (kg), PEEP 10 cm H2O or not, respiratory rate as end-tidal carbone dioxide concentration (ETCO2). During the peumoperitoneum record rSO2 every 10 minutes with respiratory parameters (Peak pressure, mean pressure, PEEP) and vital signs

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026