Depression
Conditions
Keywords
Depression, Cognitive Bias, Internet
Brief summary
This research study is designed to investigate the effects of an online computer program, called OxIGen (Oxford Imagery Generation), on thinking style and mood in depression. The OxIGen program will be delivered online over four weeks and with follow-up at one, three and six months. This will inform potential future development of this computerized task into an online intervention to modify negative thinking styles in depression.
Interventions
OTHEROxIGen
Internet-based intervention with 12 sessions over 4 weeks
OTHEROxIGen: control version
A control version of the OxIGen internet-based intervention (i.e. identical but with putative active components removed)
Sponsors
Lupina Foundation
University of Oxford
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Willing and able to give consent to the study * Male or Female, aged between 18 and 65 years * Current Major Depressive Episode (assessed by semi-structured clinical interview) * Access to internet in order to complete the online program * Able to travel to research centre for assessment appointments * Fluent in written and spoken English
Exclusion criteria
* Meets criteria for current psychotic disorder * History of mania or hypomania as assessed by semi-structured clinical interview, or has elsewhere received a diagnosis of Bipolar disorder * Antidepressant medication begun or changed in dosage during last month * Meets criteria for current substance abuse disorder * Involved in other current treatment trials * Currently receiving psychological therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in score on Beck Depression Inventory - II | Baseline and post-intervention (4 weeks) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change on EuroQol-5D | Baseline and Post-Intervention (4 weeks) | — |
| Change in Neuroticism | Baseline and Post-Intervention (4 weeks) | — |
| Change on Beck Depression Inventory - II | Baseline and Follow-Up (one month, three months, six months) | — |
| Change in score on Quick Inventory of Depressive Symptoms - Self Report | Baseline and post-intervention (4 weeks) | — |
| Change in State-Trait Anxiety Inventory (Trait scale) | Baseline and Post-Intervention (4 weeks) | — |
| Change on Beck Anxiety Inventory | Baseline and Post-Intervention (4 weeks) | — |
| Change on Scrambled Sentences Task | Baseline and Post-Intervention (4 weeks) | — |
| Change on Life Orientation Test - Revised | Baseline and Post-Intervention (4 weeks) | — |
| Change on Prospective Imagery Test | Baseline and Post-Intervention (4 weeks) | — |
| Change on Behavioural Activation in Depression Scale | Baseline and Post-Intervention (4 weeks) | — |
| Change in IAPT Toolkit | Baseline and Post-Intervention (4 weeks) | Includes the GAD-7, PHQ-9 and Work and Social Adjustment Scale |
| Change on Quick Inventory of Depressive Symptoms - Self Report | Baseline and Follow-Up (one month, three months, six months) | — |
| Change on State-Trait Anxiety Inventory (Trait scale) | Baseline and Follow-Up (one month, three months, six months) | — |
| Change on IAPT Toolkit | Baseline and Follow-Up (one month, three months, six months) | Includes GAD-7, PHQ-9, Work and Social Adjustment Scale |
| Change on Euroqol-5D | Baseline and Follow-Up (one month, three months, six months) | — |
| Change on Neuroticism | Baseline and Follow-Up (one month, three months, six months) | — |
| Image Generation Task | Post-Intervention (4 weeks) | Task adapted from Sharot et al. (2007, Nature) |
Countries
United Kingdom
Outcome results
None listed