Coronary Heart Disease
Conditions
Keywords
-CD16+ monocytes
Brief summary
Monocytes may be separated into phenotypically and functionally distinct cell types by the presence or absence of the lipopolysaccharide receptor CD14 and the Fcγ-receptor CD16. The investigators hypothesize that the total numbers of CD16+ monocytes are significantly related to cardiovascular outcome in patients with angiographically proven coronary heart disease.
Interventions
None listed
Sponsors
Martin-Luther-Universität Halle-Wittenberg
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* angiographically proven coronary heart disease * Age \> 18 years
Exclusion criteria
* life expectancy \< 12 months * inability to participate in the trial (to give written informed consent)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Absolute numbers of CD16+ monocytes stratified by tertiles related to the incidence of the combined endpoint | 12 months | Incidence of the combined endpoint (non-fatal myocardial infarction, cardiovascular death, stroke) during a follow-up of 12 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Absolute numbers of CD16+ monocytes stratified by tertiles related to the incidence of each part of the combined endpoint + total death | 12 months | * non-fatal myocardial infarction * cardiovascular death * stroke * total death |
| Subgroup analysis for absolute numbers of CD16+ monocytes stratified by tertiles in relation to the combined endpoint | 12 months | Subgroups of patients: Patients with stable Angina Patients with acute coronary syndrome |
Countries
Germany
Outcome results
None listed