Expression of Th9 Cells and Poor/Non-responsiveness to Hepatitis B Vaccination

Effect of the Expression Level of Th9 Cells and IL-9 In Poor/Non-responsiveness to Hepatitis B Vaccination

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01441609

Enrollment

Registered

2011-09-27

Start date

2011-08-31

Completion date

2012-05-31

Last updated

2011-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatitis B

Keywords

Th9 cells, IL9, non/poor responsiveness to hepatitis B, collect blood samples after vaccination

Brief summary

An observational study will be performed in subjects aged 3-65 years old to describe the dynamic changes of cellular immunity after vaccination of hepatitis B vaccine, and to find out the expression levels of Th9 cells and IL9 in subjects with different response to the primary immunization (3 single -dose injunctions).

Detailed description

This study selected 74 volunteers which had the hepatitis B vaccine (immunization programs 0,1,6) , anti-HBs≤10mIU as the research subjects, and choose 20 volunteers which anti-HBs≥1000mIU as the control group, revaccination the groups according to the normal immunization programs, then the blood samples would be collected at 7th day, separate the PBMC and detect the expression levels of Th9 cells and IL9 by FCM, trying to find out the effects of Th9 and IL9 of non/poor -responsiveness subjects to hepatitis B.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Eligibility

Sex/Gender

ALL

Age

3 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* volunteer * between 3-60 years old * healthy * have the history of vaccination of hepatitis B. * Recent serological testing result show HBsAg, HBeAg, anti-HBe, anti-HBc, HBV DNA and Pre-S1 should be negative. * informed consent * not allergic to the component of the vaccine

Design outcomes

Primary

Measure	Time frame
Th9 cells	blood sample of 7th day after each vaccination

Countries

China

Contacts

Primary ContactLi xuezhen

0476-5891156

Outcome results