Postoperative Ileus
Conditions
Keywords
Gastrografin, Postoperative ileus, Colo-rectal surgery, Effects on morbidity and mortality of postoperative ileus
Brief summary
The purpose of this trial is to determine whether the water-soluble contrast (gastrografin) is more effective in the treatment of postoperative ileus than the conventional one.
Interventions
DRUGGastrografin
Administration of 100 ml of gastrografin by the nasogastric tube, only once.
Administration of 100 ml of physiological serum 0,9% by the nasogastric tube, only once.
Sponsors
Hospital Universitari de Bellvitge
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients with postoperative ileus after colorectal surgery, defined as the presence from the third postoperative day, abdominal distension, nausea, vomiting with or without abdominal pain or discomfort by dilation of bowel loops, confirmed radiology of the abdomen, and which are: Age \> 18 years Patients undergoing laparotomy or laparoscopy for the following variants of colorectal disease with or without stoma: 1. Neoplasia. 2. Inflammatory disease. 3. Diverticular disease. Patients who have been treated with standard PCA as postoperative analgesia. Signed informed consent. Undergoing elective or scheduled
Exclusion criteria
* Patient's refusal to sign informed consent * Pregnancy or lactation * Hypersensitivity to iodinated contrast agents (it´s the only contraindication to oral Gastrografin) Presence of other problems that justify the etiology of postoperative ileus: 1. Anastomotic leakages. 2. Mesenteric vascular disease. 3. Incarcerated hernias. 4. Intra-abdominal abscesses or collections. 5. Metabolic or electrolyte disturbances. If during the course of the study one of the reasons previously cited as the etiology of postoperative ileus is present, the patient shall also be excluded. Also excluded patients undergoing emergency surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to resolution of postoperative ileus after surgery defined as time to tolerance of oral intake of solid or semisolid food | While the patient is admitted to the hospital. An average of 11 days since the intervention. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hospital stay after diagnosis of ileus | While the patient is admitted to the hospital. An average of 11 days since the intervention. | Postoperative complications were assessed in the intervening period between the immediate postoperative phase and when the patient is discharged. |
| Percentage of patients requiring total parenteral nutrition. | While the patient is admitted to the hospital. An average of 11 days since the intervention | Postoperative complications were assessed in the intervening period between the immediate postoperative phase and when the patient is discharged |
| Presence of postoperative pain and analgesic required | While the patient is admitted to the hospital. An average of 11 days since the intervention | Postoperative complications were assessed in the intervening period between the immediate postoperative phase and when the patient is discharged |
| Percentage of mortality during hospitalization. | While the patient is admitted to the hospital. An average of 11 days since the intervention | Postoperative complications were assessed in the intervening period between the immediate postoperative phase and when the patient is discharged |
Countries
Spain
Outcome results
None listed