Postoperative Nausea and Vomiting
Conditions
Keywords
Postoperative Nausea and Vomiting
Brief summary
* Gynecological surgery is associated with a high incidence of postoperative nausea and vomiting. * NK1 receptor antagonists such as aprepitant appear to be highly effective for treating acute and delayed emesis, and yet understanding of the efficacy of different doses of aprepitant is limited. * We performed a prospective, randomized, double-blinded placebo-controlled study of 123 female adults scheduled for laparoscopic hysterectomy who received 80 mg aprepitant, 125 mg aprepitant, or a placebo.
Detailed description
123 female patients (ages 21-60) undergoing laparoscopic hysterectomy 1. 80mg aprepitant 2. 125mg aprepitant 3. placebo Incidences of nausea, vomiting/retching, and use of rescue antiemetics were recorded at 0, 1, 2, 24, and 48 h after surgery.
Interventions
DRUGAprepitant
Aprepitant 80 mg, Aprepitant 125 mg
Sponsors
Asan Medical Center
University of California, San Francisco
Gachon University Gil Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
21 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* female laparoscopic hysterectomy isoflurane anesthesia postoperative opioid use
Exclusion criteria
* liver disease neurologic disease active pulmonary disease cardiac arrhythmia allergies to any perioperative medications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The numbers (and percentages) of patients who experienced complete response | 48 hours postoperatively | * The numbers (and percentages) of patients who experienced complete response, i.e. no nausea, retching, vomiting, or need for rescue treatment * required rescue therapy and peak nausea scores * Adverse effects in the three treatment groups |
Countries
South Korea
Outcome results
None listed