Chronic Systolic Heart Failure
Conditions
Keywords
Chronic heart failure, rhNRG-1, Cardiac remodeling
Brief summary
This is a multi-center, randomized, double-blind , placebo parallel controlled, standard therapy based phase III clinical trial, to evaluate the efficacy of recombinant human neuregulin-1 on cardiac remodeling, as well as safety in patients with chronic heart failure.
Detailed description
RhNRG-1(recombinant human neuregulin-1)directly works on the cardiomyocytes and restored the normal structure and function of it.Both the preclinical trial and phase II clinical trail have confirmed that rhNRG-1 effectively improved the heart function, and is tolerated in the effective dosage groups. The aim of this phase III trial is to further confirm in large population that rhRNG-1 administration can effectively improve the cardiac remodeling and is tolerated in patients with chronic heart failure.
Interventions
DRUGPlacebo
day1\ day10:0.6ug/kg/day,10hours per day for vein infusion
DRUGrhNRG-1
day1\ day10:0.6ug/kg/day,10hours per day for vein infusion
Sponsors
Zensun Sci. & Tech. Co., Ltd.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Age between 18 and 75, both sex. 2. Left ventricular ejection fraction (LVEF)≤40% (ECHO). 3. NYNA functional class II\ III. 4. Definitely diagnosed with chronic systolic heart failure (including medical records, symptoms and physical signs)and clinical symptom is steadily in the latest 1 month. 5. Receiving standard basic treatment of heart failure, has reached the objective dosage or the highest tolerated dosage for at least 1 month, or the dosage has not been changed for at least 1 month. 6. Capable of signing the informed consent form.
Exclusion criteria
1. Patients with atrial fibrillation. 2. Patients with a pacemaker. 3. Patient with a metallic implant. 4. Patient with Claustrophobia. 5. Patients with acute myocardial infarction, Hypertrophic cardiomyopathy, constrictive pericarditis, significant valvular pathological change or congenital heart diseases, severe pulmonary artery hypertension. 6. Ischemic heart failure without recanalization or with recanalization in recent six months. 7. Cardiac surgery or cerebrovascular accident within recent six months. 8. Preparing for heart transplantation or has received CRT treatment. 9. Serious hepatic or renal dysfunction caused by organic pathological changes (Cr\>2.0mg/dl, AST or ALT 5 times above the normal upper limit). 10. Patients need mechanical ventilation. 11. Systolic blood pressure \<90mmHg or \>160mmHg. 12. Patients with acute hemodynamic disorder or decompensation in the last 1 month. 13. Serious ventricular arrhythmia (multi-morphological premature ventricular contraction, frequent paroxysmal ventricular tachycardia). 14. Serum potassium \<3.2 mmol/L or \>5.5 mmol/L. 15. Pregnant or plan to pregnant. 16. Unmarried or married but not procreated women at child-bearing age. 17. Subject with a life expectancy less than 6 months as assessed by the investigator. 18. Patients who participated in any clinical trial in the recent three months. 19. History of any malignancy or suffering from cancer,or biopsy proven pre-malignant condition (eg DICS or cervical atypia). 20. Evidence (physical examination,CXR,ECHO or other tests) shows some active malignancy or adenoidal hypertrophy or neoplasm has effect on heart function or endocrine system, eg pheochromocytoma or hyperthyroidism. 21. Judging by the investigator, the patients could not complete the study or adhere to the study requirements (due to the management reasons or others).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left Ventricular Ejection Fraction | 30 days |
Secondary
| Measure | Time frame |
|---|---|
| Left Ventricular Ejection Fraction | 90 days |
| N-terminal pro-BNP | 30 days and 90 days |
Countries
China
Outcome results
None listed