Acute Lymphoblastic Leukemia
Conditions
Keywords
Acute lymphoblastic leukemia, Survivor, Sibling control
Brief summary
Specific Aim: Compare the endothelial function, arterial stiffness and components of metabolic syndrome of childhood Acute Lymphoblastic Leukemia (ALL) survivors to healthy sibling controls. Plan: A cross sectional study comparing ALL survivors to sibling controls including measures of endothelial function and arterial stiffness obtained form a peripheral artery tonometry device, height, weight, waist circumference, fasting lipid, glucose and insulin.
Interventions
None listed
Sponsors
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
8 Years to 28 Years
Healthy volunteers
Yes
Inclusion criteria
Survivor: Inclusion 1. Ages 8-28 (8 is chosen as lower age limit because developmental understanding will allow survivor to follow instructions for procedures, 28 is chosen as upper limit to include age ranges seen for treatment in the pediatric program) 2. Off therapy for at least 6 months and not more than 10 years (6 months Inclusion 1. Biological sibling 2. Ages 8-28 (when more than one sibling is available the one closest in age will be chosen.))
Exclusion criteria
1. Uncontrolled medical conditions that could interfere with participation or interpretation of results 2. History of relapsed ALL or history of bone marrow transplantation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| measure of endothelial | at enrollment |
Countries
United States
Outcome results
None listed