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Early Intervention for Adolescents With Patellofemoral Pain Syndrome

Early Intervention for Adolescents With Patellofemoral Pain Syndrome - a Cluster Randomized Trial

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01438762
Enrollment
102
Registered
2011-09-22
Start date
2011-06-30
Completion date
2014-02-28
Last updated
2016-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patellofemoral Pain Syndrome

Keywords

Anterior Knee Pain

Brief summary

Self-reported, unspecific knee pain is highly prevalent among adolescents. A large proportion of the unspecific knee pain can be attributed to Patellofemoral Pain Syndrome (PFPS). There are a number of treatment options for PFPS. Physical therapy has been advocated as one of the cornerstones in rehabilitation of patients with PFPS. Twenty-five years ago, McConnell proposed a multimodal approach that combined several treatment options. The regimen included retraining of the vastus medialis oblique muscle through functional weight bearing activities. This exercise is combined with patellar taping, patellar mobilization, and stretching to improve patellar tracking, reduce pain, and enhance vastus medialis oblique muscle activation. Short term results (\<12 months) indicates that multimodal physiotherapy is more effective than placebo treatment. While treatment for PFPS may be successful for the short-term, long-term results are less promising. A recent review covering the long term prognosis for patients diagnosed with PFPS, reported that only 1/3 of those diagnosed with PFPS and treated conservatively were pain free 12 months after diagnosis. Further ¼ stopped participating in sports because of knee pain. Predictors of long term outcome (\>52weeks) indicate that a long symptom duration, higher age and greater severity at baseline are associated to poorer outcome after treatment. These prognostic factors suggest that an early initiation of treatment might lead to a better long-term prognosis. The purpose of this study is to examine the short and long-term effectiveness of multi-modal physiotherapy compared to standard wait-and-see treatment applied at a very early state of disease among adolescents. The investigators hypothesized a significantly larger proportion of completely recovered patients at three-month follow-up in the interventions group compared to the control group.

Interventions

BEHAVIORALPatient information and education

All subjects will receive one-to-one patient education delivered by a physiotherapist. The information will be standardized and cover the topics of: why does it hurt: pain management; information of how to reduce physical activity if necessary; how to return slowly to sports; how to cope with knee pain and information of how to increase knee alignment during walking and stair walking. The patients will also receive this information in written form. This information is expected to take approximately 45minutes per patient.

OTHERInformation, education and physiotherapy

Patients will receive one-to-one patient education delivered by a physiotherapist. The information will be standardized and cover the topics of: why does it hurt: pain management; information of how to reduce physical activity if necessary; how to return slowly to sports; how to cope with knee pain and information of how to increase knee alignment during walking and stair walking. The patients will also receive this information in written form. In addition the patients will receive supervised multimodal physiotherapy carried out by a physiotherapist with previous experience in treating adolescents and PFPS and has more than two years of practical experience in these areas. The multimodal physiotherapy intervention will be carried out at school premises right after the end of class.

Sponsors

University of Southern Denmark
CollaboratorOTHER
Aarhus University Hospital
CollaboratorOTHER
Mogens Berg Laursen
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
15 Years to 19 Years
Healthy volunteers
No

Inclusion criteria

* Age 15-19 years * Insidious onset of anterior knee or retropatellar pain of greater than six weeks' duration * Provoked by at least two of prolonged sitting or kneeling, squatting, running, hopping, or stair walking * Tenderness on palpation of the patella, or pain with step down or double leg squat * Worst pain over the previous week of at least 30 mm on a 100 mm visual analogue scale.

Exclusion criteria

* Concomitant injury or pain from the hip, lumbar spine, or other knee structures * Previous knee surgery * Patellofemoral instability * Knee joint effusion * Use of physiotherapy for treating knee pain within the previous year * Use of weekly use anti-inflammatory drugs.

Design outcomes

Primary

MeasureTime frameDescription
Change in perception of recovery after 12 months measured on a 7-point likert scale ranging from completely recovered to worse than ever.Baseline, 3, 6, 12 and 24monthsPerception of recovery after 12 months measured on a 7-point likert scale ranging from completely recovered to worse than ever.

Secondary

MeasureTime frameDescription
Knee Injury and Osteoarthritis Outcome ScoreBaseline, 3, 6, 12 and 24months
EQ5DBaseline, 3, 6, 12 and 24months
Neuromuscular functionBaseline and 3 monthsEach subjects will undergo quadriceps strength measurements and two basic tests of neuromuscular function of m. vastus medialis and m. vastus lateralis. EMG will be collected during two different conditions: Walking and semi-squat at 90 degrees flexion at the knee joint.

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 27, 2026