Gynecological Disease, Healthy Adults
Conditions
Keywords
Pain, Postoperative, Anesthetics, intravenous, Anesthetics, inhalation, Otherwise healthy adults undergoing general anesthesia for gynecological disease.
Brief summary
The impact of anaesthetic method (intravenous vs. inhalational) has been proposed, but not proven in a large-scale study. The researchers aim to provide an investigation that has sufficient power to clarify the potential effect of anaesthetic method on postoperative need of opioids. Sevoflurane and propofol will be compared.
Interventions
DRUGSevoflurane
Sevoflurane inhalation anesthesia, sufficient amount to maintain adequate general anesthesia for surgery
DRUGPropofol
Propofol intravenous anesthesia, sufficient amount to maintain adequate anesthesia during surgery
Sponsors
Tampere University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 69 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-69 years * Gender: female * ASA status 1-3 * Laparoscopic hysterectomy
Exclusion criteria
* Body Mass Index over 35 * Diabetes mellitus * Liver disease * Allergies to pharmaceuticals used in the Study * Present use of opioids
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative consumption of an opioid (oxycodone) | 20 hours | The consumption of oxycodone will be monitored by recording the amount of the drug received via a commercially available patient controlled analgesia (PCA) pump. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| NRS (numeral rating scale) of pain | 20 hours | NRS is evaluated frequently during the study period. |
Countries
Finland
Outcome results
None listed