Acute Respiratory Distress Syndrome
Conditions
Keywords
Acute respiratory distress syndrome, Children, Long term respiratory sequelae, Pulmonary function tests, Computed tomography, lung
Brief summary
The purpose of this study is to assess long term (1 year) respiratory sequelae in children surviving an acute respiratory distress syndrome
Detailed description
The acute respiratory distress syndrome (ARDS) has a high mortality rate in children. Adverse long term sequelae, and in particular respiratory sequelae, have been described mainly in adults. Decrease in diffusing capacity, lung volume and exercise tolerance were observed. Lung function parameters improve during the follow-up until 6 month after discharge from the pediatric intensive care unit (PICU). After that, abnormalities in PFT are observed in a significant proportion of patients. Only two studies described long-term sequelae in children surviving to an ARDS and their results are conflicting. Two studies carried out in adults described the morphologic long-term sequelae by thoracic computed tomography. They showed reticular pattern with a striking anterior distribution in most patients evaluated more than 6 months after discharge from the PICU. There is, to our knowledge, no study describing morphologic pulmonary sequelae by thoracic computed tomography in children surviving to ARDS. Respiratory assessment: respiratory sequelae in children surviving to the acute respiratory distress syndrome will be evaluated 1 year after discharge from the PICU. Assessment will include a clinical evaluation (respiratory history and physical examination), respiratory function tests and thoracic computed tomography
Interventions
None listed
Sponsors
University Hospital, Lille
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
* children surviving to an acute respiratory distress syndrome and alive 1 year after discharge from the PICU
Exclusion criteria
* children suffering from neuromuscular disease * children presenting symptoms of chronic respiratory disease before ARDS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dynamic lung compliance | 1 year +- 2 months after discharge from ICU |
Secondary
| Measure | Time frame |
|---|---|
| respiratory complaints (cough, wheeze,dypnea at rest on exertion, bronchitis, pneumonia | 1 year +- 2 months after discharge from ICU |
| extend of ground glass opacification (CT scan) | 1 year +- 2 months after discharge from ICU |
| extend of intense parenchymal opacification | 1 year +- 2 months after discharge from ICU |
| extend of reticular pattern | 1 year +- 2 months after discharge from ICU |
| extend of decreased attenuation due to emphysema | 1 year +- 2 months after discharge from ICU |
| extend of decreased attenuation attributable to small-airway disease | 1 year +- 2 months after discharge from ICU |
| carbon monoxide diffusing capacity | 1 year +- 2 months after discharge from ICU |
| Pulse oxymetry oxygen saturation at the end of a 6 min walk test | 1 year +- 2 months after discharge from ICU |
Countries
Belgium, France
Contacts
STUDY_CHAIRFrancis Leclerc, MD
University hospital of Lille , France
Outcome results
None listed