Low Back Pain
Conditions
Keywords
epidural steroid injection, triamcinolone, fasting blood glucose, diabetes mellitus
Brief summary
There has been no reports of the effect of various kinds of steroid or various dose of steroid which are commonly used in the clinical setting. Previous studies have simply shown that the blood glucose level is elevated in diabetes patients and did not show or suggest the adequate strategy of epidural steroid injection in diabetes patients regarding steroid type, dosage or injection interval. Therefore, the investigators tried to evaluate the effect of different dosage of triamcinolone, which is a commonly used steroid in epidural steroid injection, on the blood glucose level.
Detailed description
It is well known that blood glucose level is elevated in diabetes patients more than non-diabetes patients who underwent the epidural steroid injection. However, there has been no reports of the effect of various kinds of steroid or various dose of steroid which are commonly used in the clinical setting. Previous studies have simply shown that the blood glucose level is elevated in diabetes patients and did not show or suggest the adequate strategy of epidural steroid injection in diabetes patients regarding steroid type, dosage or injection interval. Therefore, the investigators tried to evaluate the effect of different dosage of triamcinolone, which is a commonly used steroid in epidural steroid injection, on the blood glucose level.
Interventions
OTHERepidural steroid injection with Triamcinolone 40mg
epidural steroid injection with Triamcinolone 40mg
OTHERSelective transforaminal epidural block with triamcinolone 20 mg
Selective transforaminal epidural block with triamcinolone 20 mg
OTHERcaudal epidural steroid injection with Triamcinolone 20mg
caudal epidural steroid injection with Triamcinolone 20mg
OTHERSelective transforaminal epidural block with triamcinolone 40 mg
Selective transforaminal epidural block with triamcinolone 40 mg
Sponsors
Samsung Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* subjects who undergo epidural steroid injection (caudal epidural injection or selective transforaminal block) in the pain medicine outpatient clinic * subjects older than 20 yrs.
Exclusion criteria
* ASA (American society of Anesthesiologists class) III or more * severe cardiopulmonary disease or brain disorder * Subjects diagnosed uncontrolled diabetes with complications * subjects undergoing hormone therapy * subjects with active infection * subjects with pregnancy * subjects with recent stress condition such as surgery or trauma * subjects with active neurologic disorder * those with anticoagulation therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fasting blood glucose level | at 7:00 am of postprocedure day 1 | before breakfast (fasting state) |
| fasting blood glucose | at 7:00 am of postprocedure day 14 | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| post-prandial glucose level | 2 hour after dinner at postprandial day 1, 2, 3, 4, 5, 6, 7, 14 | 2 hour after dinner |
| visual analogue scale of subjective pain | at 7 p.m. of postprocedure day 1, 2, 3, 4, 5, 6, 7, 14 | at 7:00 am of postprocedure day 5 |
Countries
South Korea
Outcome results
None listed