Detection of Helicobacter Pylori Infection by High Resolution Endoscopy

Detection of Helicobacter Pylori Infection by Non-magnifying High Resolution Endoscopy is Possible Within the Gastric Corpus

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01434992

Enrollment

585

Registered

2011-09-15

Start date

2011-08-31

Completion date

2012-01-31

Last updated

2012-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter-associated Gastritis

Brief summary

Although endoscopic findings of H. pylori have been reported in the literature, there is still some debate over whether H. pylori-related gastritis can be diagnosed via endoscopic features alone. Most studies concluded that it is not possible to diagnose H. pylori-related gastritis on the basis of endoscopic findings. However, the resolution power of endoscopy has greatly improved in recent years and the exact examination of gastric mucosa was possible.

Detailed description

Our study aimed to achieve the following: (1) describe the H. pylori-related mucosal pattern in the gastric corpus using high-definition endoscopy; (2) evaluate the diagnostic accuracy for H. pylori detection; (3) find the optimal biopsy site for rapid urease test (RUT); (4) validate the inter- and intraobserver agreement in the assessment of endoscopic patterns.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Patients who underwent upper endoscopy

Exclusion criteria

* Age \< 20 or \> 70 * Severe systemic disease or advanced chronic liver disease * Medication history of NSAID, PPI, H2 blockers or antibiotics * History of H. pylori eradication therapy * History of gastric surgery * Recent history of upper GI bleeding * Gastric or duodenal ulcer (including old scar change) during endoscopy * Anemia (Hemoglobin level \< 10mg/dL) * Pangastritis

Design outcomes

Primary

Measure	Time frame
Diagnosis accuracy for predicting of Helicobacter pylori infection status	1 day

Secondary

Measure	Time frame
Assessment of the clinicopathologic factors related to correct diagnosis	7 days

Countries

South Korea

Outcome results