Ischemic Lesions
Conditions
Keywords
Ischemic, preconditioning, liver, resection
Brief summary
Vascular occlusion is used to reduce blood loss during liver resection (LR), but may cause ischemic damage to the remnant liver and can lead to liver failure in case of chronic liver disease. This restriction of blood flow (ischemia) and subsequent restoration (reperfusion) causes a harm that is called ischemia- reperfusion injury. Injuries sustained during the ischemic phase are related to a lack of oxygen to reduce cellular respiratory events can lead to, in a few minutes, irreversible damage. Ischemic preconditioning as a technique to protect the liver parenchyma during liver resection consists of an initial flow clamping for 10 minutes, with subsequent reperfusion for 10-15min, followed by a complete portal triad clamping during transection.
Detailed description
Detailed Description: This is a prospective controlled trial, conducted between July 2011 and July 2012. This study has been initiated by Liver & Transplant Division, Hospital Dr Cosme Argerich, Buenos Aires Argentina. The protocol was approved by ethics committees and an informed consent was obtained from each patient before they were enrolled. Sixty patients were randomized to either receive ischemic preconditioning prior to liver resection under intermittent pedicle clamping or Intermittent Pringle ischemia. Ischemic preconditioning was performed through a sequence of 10 minutes vascular inflow occlusion and 10 minutes of reperfusion prior to continuous pedicle clamping during resection. Intermittent pedicle clamping was conducted through a sequence of 15 minutes of vascular inflow occlusion and 5 minutes of reperfusion. The randomization process which was centralized was held in the operating room after inclusion criteria had been check and exclusion criteria ruled out.
Interventions
PROCEDUREischemic preconditioning
Surgery with ischemic preconditioning in liver resection
Sponsors
Hospital General de Agudos Dr. Cosme Argerich
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* patients' age ≥ 18 years old * Portal vein embolization allowed
Exclusion criteria
* laparoscopic liver resection * pregnant women * lack of patient consent * lack of acceptance of the operating surgeon * Hilar cholangiocarcinoma * Simultaneous hepaticojejunostomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality Complications | within 30 days after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Operative variables,markers of liver function and injury, pathological parenchymal characteristics | within 30 days after surgey | Operative time Transection time Operative blood loss Transection area Intraoperative haemodynamic and gases parameters (CVP, MAP) Requirement of blood products. ICU and total length of hospital stay Markers of liver function (Bilirrubin, prothtrombin time) Markers of liver injury (aspartate aminotransferase (AST), alanine aminotransferase (ALT) Pathological parenchymal characteristics |
Countries
Argentina
Contacts
Primary ContactJavier Lendoire, MD, PhD
Outcome results
None listed