Colorectal Lesion
Conditions
Keywords
narrow band imaging, learning curve, colorectal, differential diagnosis, with colorectal lesion, NBI with magnification
Brief summary
It exists a learning curve in using NBI with magnification to differentiating colorectal lesions.
Detailed description
It is very useful to use narrow-band imaging and Sano CP analysis in the differential diagnosis of colorectal lesions. The endoscopists who had never used NBI or no knowledge of NBI can have effective and stable diagnostic accuracy after using NBI with magnification to diagnose 15 target and non-target lesions respectively.
Interventions
None listed
Sponsors
Zhizheng Ge
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Ages 16 to 85 * Any patient undergoing NBI with magnification colonoscopy exam and found with colorectal lesions
Exclusion criteria
* Unwilling to consent * Had surgery of colorectal tumors * Using NSAIDS * Diagnosed or suspected IBD * Familial adenomatous polyposis(FAP) or hereditary non-polyposis colorectal(HNPCC) or other hereditary disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy, Sensitivity, and Specificity for Differentiating Neoplastic and Non-neoplastic Lesions | For this training, patients were consecutively enrolled until a total of 45 target and non-target lesions were obtained. |
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| NBI With Magnification Patients with lesions diagnosed by Sano classification using NBI with magnification | 326 |
| Total | 326 |
Baseline characteristics
| Characteristic | NBI With Magnification |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 97 Participants |
| Age, Categorical Between 18 and 65 years | 229 Participants |
| Age, Continuous | 57.4 years STANDARD_DEVIATION 10.9 |
| Gender Female | 131 Participants |
| Gender Male | 195 Participants |
| Region of Enrollment China | 326 participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 0 / 326 |
| serious Total, serious adverse events | 0 / 326 |
Outcome results
Primary
Accuracy, Sensitivity, and Specificity for Differentiating Neoplastic and Non-neoplastic Lesions
Time frame: For this training, patients were consecutively enrolled until a total of 45 target and non-target lesions were obtained.
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| NBI With Magnification | Accuracy, Sensitivity, and Specificity for Differentiating Neoplastic and Non-neoplastic Lesions | Accuracy | 94.3 percentage of lesions |
| NBI With Magnification | Accuracy, Sensitivity, and Specificity for Differentiating Neoplastic and Non-neoplastic Lesions | Sensitivity | 98.0 percentage of lesions |
| NBI With Magnification | Accuracy, Sensitivity, and Specificity for Differentiating Neoplastic and Non-neoplastic Lesions | Specificity | 92.0 percentage of lesions |