Ovarian Cyst
Conditions
Keywords
Pharmacokinetics, kidney;, Receptors, adrenergic;, Fluids, i.v.;, Sympathetic nervous system, esmolol;, Sympathetic nervous system, phenylephrine
Brief summary
The aim this study was to examine to what degree the slow turnover of lactated Ringer's solution during anesthesia and surgery can be prevented by infusing esmolol (a ß1-receptor blocker) or phenylephrine in patients undergoing laparoscopic gynecological surgery performed under intravenous anesthesia.
Detailed description
INTRODUCTION The renal clearance of infused crystalloid fluid is very low during anaesthesia and surgery, but experiments in conscious sheep indicate that the renal fluid clearance might approach a normal rate when the adrenergic balance is modified. METHODS Sixty females (mean age, 32 years) undergoing laparoscopic gynecological surgery were randomized to control group and received only the conventional anesthetic drugs and 20 ml/kg of lactated Ringer's over 30 min. The others were also given an infusion of 50 µg/kg/min of esmolol (beta1-receptor blocker) or 0.01 µg/kg/min of phenylephrine (alpha1-adrenergic agonist) over 3 hours. The distribution and elimination of infused fluid was studied by volume kinetic analysis based on urinary excretion and blood Hgb level.
Interventions
50 µg/kg/min of the ß1-receptor-blocker esmolol was infused intravenous over 3 hours
0.01 µg/kg/min of the alpha-1-adrenergic receptor agonist phenylephrine
DRUGLactated Ringer´s solution
Intravenous Infusion of 10 ml/h lactated Ringer's solution that contained no drug
Sponsors
Zhejiang University
Sodertalje Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Caregiver)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* ASA group I * Scheduled for laparoscopic removal of ovarian cyst or laparoscopic hysterectomy
Exclusion criteria
* ASA group \> I * Daily medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urinary excretion | 3 hours | Urine was collected via an indwelling catheter during 3 hours of surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Volume kinetics of lactated Ringer´s solution | 3 hours | Volume kinetics was analyzed based on serial analysis of the blood Hgb concentration and the collection of urine. Distribution between a central body and a peripheral body fluid space was then calculated over time. |
Countries
China
Outcome results
None listed