Invasive Aspergillosis
Conditions
Keywords
aspergillosis, bronchoalveolar lavage, galactomannan, pcr, hematological patients
Brief summary
Diagnosing invasive pulmonary aspergillosis (IPA) remains a challenge in patients (pts) with hematological malignancies. The clinical significance of testing bronchoalveolar lavage (BAL) samples both with polymerase chain reaction (PCR) and Aspergillus galactomannan (GM) ELISA is unclear, and the BAL cutoff for GM has not been clearly defined yet. Using a validated nested PCR assay and a GM ELISA, we prospectively examine BAL samples from hematological patients at high risk of PA.
Interventions
None listed
Sponsors
Heidelberg University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
\- hematological patients with lung infiltrates at high risk for invasive aspergillosis
Exclusion criteria
\- patients without informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical significance of biomarker based diagnostic investigation in suspected invasive aspergillosis | up to 18 months |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of diagnostic and therapeutic intervention concerning antifungal treatment with regard to outcome (overall survival, in months) of a fungal infection | up to 18 months |
Countries
Austria, Germany
Outcome results
None listed