Sterility
Conditions
Keywords
Oral estrogens, transdermal estrogens, endometrial priming
Brief summary
The aim of this trial is compare two different endometrial priming protocols * women that receive oral estrogens * women that receive transdermal estrogens
Interventions
DRUGOral strogen
2 mg of estradiol every day beginning the second day of the cycle until day 7. 4 mg of estradiol every day beginning 8th day of the cycle until day 10. 6 mg of estradiol every day beginning 11th day of the cycle until day 16.
DRUGTransdermal strogen
One patch of 75 mcg of estradiol hemimydrate every 48 h from 2 to day 6. Two patches of 75 mcg of estradiol hemimydrate every 48 h from 6 to day 12. Three patches of 75 mcg of estradiol hemimydrate every 48 h from 12 to day 16.
Sponsors
Parc de Salut Mar
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Women between 18-50 years old with desire of children and needs of embryo transfer. * Plasma prolactin less than 30. * Uterine cavity that allow pregnancy, body mass index between 20-30. * And signed consent inform.
Exclusion criteria
* History of estrogen dependent cancer, unknown origin vaginal bleeding. * Ovarian cyst. * Contraindications to be pregnant. * Estrogen allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference between day means in endometrial priming to achieve 7 mm. | 11-16 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Biochemical Pregnancy rate | 26-30 days | To calculate the biochemical pregnancy rate, we will divide the number of biochemical pregnancy into the number of embryonary transference and multiply by 100. |
| The patient's adherence to the recommended treatment. | 1-16 days | — |
Countries
Spain
Outcome results
None listed