Physical Activity for a Long and Healthy Life

Physical Activity for a Long and Healthy Life - Project FINE

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01430143

Acronym

FINE

Enrollment

Registered

2011-09-07

Start date

2009-09-30

Completion date

2011-06-30

Last updated

2018-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus, Type 2, Insulin Resistance, Overweight

Keywords

Exercise

Brief summary

The aim of the study is to 1) delineate the molecular mechanisms behind the large variation in insulin sensitivity among apparently healthy subjects and to 2) establish the dose-response relationship between physical training and a) metabolic health, b) appetite and c) cultural health.

Interventions

BEHAVIORALExercise

Daily exercise for 12 weeks.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

20 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy according to interview * Caucasian * Sedentary, Vo2max \< 45 ml/kg/min * BMI 25-30 kg/m2 * Fat percentage 25% \< * Weight stable (+/- 2 kg within past 6 months)

Exclusion criteria

* First degree relatives with type 2 diabetes * Hemoglobin concentration \< 8 mmol/l * Fasting plasma glucose 6.1 mmol/l \< * Blood pressure 140/90 mmHg \< * Regular intake of medicine

Design outcomes

Primary

Measure	Time frame	Description
Change from baseline in insulin sensitivity at 12 weeks	At baseline and 12 weeks	As measured by a hyperinsulinemic, isoglycemic clamp combined with skeletal muscle and adipose tissue biopsies as well as low-dose PET/CT.

Secondary

Measure	Time frame	Description
Change from baseline in body composition af 2, 6 and 12 weeks	At baseline, 2, 6 and 12 weeks	As measured by DEXA- and MRI-scanning.
Change from baseline in appetite at 12 weeks	At baseline and 12 weeks	As measured by food records, controlled diets, meal tests and appetite hormones
Motivational factors for exercise	During and for up to 1½ year after the intervention	Ethnographic field work
Diameter of t-tubuli in skeletal muscle	At baseline	As measured in skeletal muscle biopsies by electron and confocal microscopy

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026