Psoriasis
Conditions
Brief summary
Objective(s): (i) To assess the effect of adjunctive topical steroids in the combined treatment with UVBnb and dithranol on the remission time after therapy till a relapse of psoriasis defined as 50% loss of PASI (Psoriasis Area and Severity Index) improvement obtained through the antecedent treatment. (ii) To assess the impact of adjuvant topical steroids in the combined treatment with UVBnb and dithranol on the clearing time of psoriasis lesions under therapy (PASI 75). * Trial with medicinal product
Detailed description
(i) To assess the effect of adjunctive topical steroids in the combined treatment with UVBnb and dithranol on the remission time after therapy till a relapse of psoriasis defined as 50% loss of PASI (Psoriasis Area and Severity Index) improvement obtained through the antecedent treatment. (ii) To assess the impact of adjuvant topical steroids in the combined treatment with UVBnb and dithranol on the clearing time of psoriasis lesions under therapy (PASI 75). * Trial with medicinal product
Interventions
DRUGSteroid active treatment
Triamcinolone in unguentum leniens 0.1%
Sponsors
University of Zurich
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Moderate to severe psoriasis of the chronic-plaque and / or guttata type
Exclusion criteria
* Participation in a Goeckerman therapy regimen within 6 months previous to the present study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relapse 50% PASI after treatment, time to PASI 75% on treatment | 2 years | Relapse 50% PASI after treatment, time to PASI 75% on treatment |
Countries
Switzerland
Outcome results
None listed