Coronary Heart Disease, Heart Valve Diseases
Conditions
Brief summary
The purpose of the study is to study if coronary angiography cause cognitive dysfunction.
Detailed description
We have previously shown, using transcranial doppler, that coronary angiography cause cerebral microembolism. Cerebral microemboli were more common using the radial than femoral approach. Previously, cerebral microembolism has been associated with new cerebral lesions on MRI. The clinical significance of these new lesions is not determined. The primary aim of this pilot study is to see if coronary angiography cause cognitive dysfunction determined by the MoCA-test. A secondary aim is to relate cognitive dysfunction to cerebral microembolism measured by transcranial doppler. A third aim is to study potential differences between the femoral and radial approaches.
Interventions
PROCEDUREArterial approach
Randomization to right radial or femoral approach
Sponsors
Karolinska Institutet
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
35 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Elective coronary angiography irrespective of cause
Exclusion criteria
* Previous CABG, language problems, not willing to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in cognitive dysfunction from baseline to two days after coronary angiography | Baseline and two days | The Montreal Cognitive Assesment test will be performed before, 2 and 30 days after coronary angiography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients with cerebral microemboli | Baseline | Cerebral microembolism will be studied by transcraniell doppler at the time of angiography. Findings will be related to change in cognitive function between baseline and two days. |
Countries
Sweden
Outcome results
None listed