Brain Lesion, Cardiac Arrhythmia, Stroke
Conditions
Keywords
Marathon running, Brain MRI, ECG recording, Blood tests
Brief summary
This prospective observational study will investigate the frequency of new onset atrial fibrillation (AF) and of further cardiac arrhythmias as well as of (clinically silent) cerebral lesions in endurance runners before, during and after the BMW-Berlin Marathon 2011.
Detailed description
Up to 120 experienced marathon runners will participate in the Berlin Beat of Running Study and will wear a transportable electrocardiogram (ECG) recorder at least 24 hours before, during and 24 hours after the BMW-Berlin Marathon. All participants will undergo brain MRI examinations to detect cerebral lesions within days before and after the marathon race, respectively. Moreover, serial blood samples will be taken a few days before, immediately after as well as a few days after the BMW-Berlin Marathon.
Interventions
None listed
Sponsors
Center for Stroke Research Berlin
Medical Institute BMW-Berlin Marathon, Berlin, Germany
Charite University, Berlin, Germany
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
35 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 35-65 years * at least 2 marathon runs within the last 5 years * weekly running of at least 40 km
Exclusion criteria
* Known cardiac arrhythmia or prior stroke * contraindication for MRI.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of cardiac arrhythmias in marathon runners detected by mobile ECG-recording | Up to 48 hours after the marathon race. | During ECG recording |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of (clinically silent) cerebral lesions detected by 3 Tesla brain MRI. | 3 days | Up to 3 days after marathon. |
Countries
Germany
Outcome results
None listed