Study of Prevalence of Colorectal Adenoma in 30- to 49-year-old Subjects With a Family History of Colorectal Cancer

Prevalence of Colorectal Adenoma in 30- to 49-year-old Asymptomatic Subjects With a First Relative History of Colorectal Cancer

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01428752

Enrollment

1000

Registered

2011-09-05

Start date

2011-09-30

Completion date

2014-09-30

Last updated

2011-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Neoplasms

Keywords

colonoscopy, colorectal neoplasms, screening, family history

Brief summary

Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer are controversial. The aim of this study was to prospectively define the prevalence of colorectal adenoma 30- to 49-years-old asymptomatic subjects with a first relative history of colorectal cancer and to compare the data with controls. Design: Single-center prospective study

Detailed description

Colorectal cancer screening is recommended for average-risk persons beginning at age 50. A family history of colorectal cancer is recognized as a risk factor for colorectal adenoma. However, the strength of this association is uncertain. Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer have proved controversial. The conflicting recommendations are partly attributable to the lack of data about the prevalence of CRC and adenomas among 30- to 49-year-old individuals with a first relative history of colorectal cancer. This prospective study will quantify the prevalence of adenomas (any size) and advanced adenomas among 30- to 49-year-old individuals undergoing their first screening colonoscopy because of a first relative history of colorectal cancer and compare the data with controls(asymptomatic subjects without a first relative history of colorectal cancer).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to 49 Years

Healthy volunteers

Inclusion criteria

* 30- to 49-year-old asymptomatic subjects * First relative history of colorectal cancer

Exclusion criteria

* previous colonoscopy for any reason * personal history of colorectal adenomas or CRC * history of familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer, or inflammatory bowel disease * documented history of occult GI bleeding, lower gastrointestinal tract bleeding not attributable to hemorrhoid, or * iron deficiency anemia * unexplained weight loss of \>10% of the body weight in the 6 months before colonoscopy * incomplete examination of entire colon

Design outcomes

Primary

Measure	Time frame
prevalence of colorectal adenoma(any size)	First screening colonoscopy

Secondary

Measure	Time frame	Description
prevalence of advanced adenoma	First screening colonoscopy	1. Any adenoma ≥10 mm 2. Any villous component 3. High-grade dysplasia

Countries

South Korea

Contacts

Primary ContactJAEIL KIM, M.D

pianojaeil@nate.com82230105673

Backup ContactKYUNG-JO KIM, M.D

capsulendos@gmail.com82230103196

Outcome results