Blood Mercury Levels Following Retrograde Amalgam Surgeries

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01428609

Enrollment

Registered

2011-09-05

Start date

2009-09-30

Completion date

2010-12-31

Last updated

2012-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Mercury Concentration

Keywords

Amalgam, Mercury, Endodontics, Apicoectomy

Brief summary

The aim of this study is to determine the blood's mercury level of patients who had amalgam root end filling surgeries. It is to be examined if the mercury concentration in blood is elevated by using amalgam retroseal.

Detailed description

* A total of 14 patients who needs surgical root canal therapy (SRCT) participated in this clinical study. * The Isfahan University Human Subjects Review Committee approved the protocol of the study. * All patients filled in the consent form. * Apicoectomy with retrograde amalgam filling performed for all participant. * Blood samples were collected in three period of time immediately before and immediately after each surgery and also one week later. * Each time 10 ml blood was drawn from each patient. * Analysis of total mercury in blood samples was performed using cold-vapor atomic absorption spectrometry

Interventions

PROCEDUREAmalgam

In all surgical intervention a zinc free amalgam (Tytin. Kerr Sybron Crop., Romulus, MI) was used in the root end prepared spaces as root end filling material. Blood samples were collected in three period of time immediately before and immediately after each surgery and also one week later.

Study design

Allocation

Intervention model

SINGLE_GROUP

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* older than 18 years * without physician-diagnosed psychological, behavioral, neurological, immunosuppressive, or renal disorders * having a tooth that required apical surgery

Exclusion criteria

* using tobacco and alcohol one week before surgery and during the study * dealing with mercury in their job like dentists, stonemason, mine workers

Design outcomes

Primary

Measure	Time frame
Blood mercury concentration	within the 7 days after surgery

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026