Study of the Aerosol Deposition With Vented and Unvented Jet Nebulizer in Healthy Subjets

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01428323

Enrollment

Registered

2011-09-02

Start date

2011-01-31

Completion date

2011-09-30

Last updated

2011-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aerosol Drug Therapy

Brief summary

Open-vent jet nebulizers are frequently used to promote drug lung deposition but their clinical efficacy and indications are not clear. Our study aimed to compare inhaled mass, and lung deposition of amikacin by using a jet nebulizer (Sidestream) under two different configurations: vented and unvented coupled to a 110 ml corrugated piece of tubing.

Interventions

DEVICEVented and Unvented Jet Nebulizer

Nebulizers used with 500mg aminoglycosides in 4ml until One minute after the sputerring point.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy Volunteers between 18 and 60 years old

Exclusion criteria

* Smokers * Pathological spirometry * History of treatment with aminoglygosides 1 month prior the study * Known allergy to aminoglycosydes * Any lung pathology or history of lung surgery

Design outcomes

Primary

Measure	Time frame
Amikacin Urinatory excretion	Each miction during 24 hours

Countries

Belgium

Contacts

Primary ContactLaurent NP Pitance, PT

laurent.pitance@uclouvain.be+3227645711

Backup ContactGiusepe Liistro, MD

Giusepe.liistro@uclouvain.be+3227642843

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026