Inflammatory Response After Colorectal Cancer Surgery

Inflammatory Response Following Colorectal Cancer Surgery Depends on the Type of Anesthesia and Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01427647

Acronym

CRC

Enrollment

Registered

2011-09-01

Start date

2007-06-30

Completion date

2010-02-28

Last updated

2016-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer

Keywords

Laparoscopy, Anesthesia, Epidural

Brief summary

Laparoscopic technique and epidural anesthesia have been proposed to improve postoperative outcome following colorectal cancer surgery. The investigators hypothesize that the inflammatory response is attenuated by laparoscopic surgery and epidural anesthesia compared to traditional open surgery under general anesthesia.

Detailed description

Patients scheduled for open colorectal cancer surgery were randomly allocated to receive general anesthesia (CON group, n=22) or general anesthesia with thoracic epidural anesthesia (EPI group, n=21). Patients undergoing laparoscopic surgery (LAP group, n=20) composed the third arm of the study. Measurement of perioperative changes in several hormones and cytokines were blinded to group assignment. Primary outcome: Compare simultaneously two types of surgical and anesthesia techniques for colorectal cancer surgery and measure to what extent the stress response is lessened.

Interventions

PROCEDURELaparoscopic technique and thoracic epidural anesthesia

We have compared colorectal cancer surgery under two types of surgical(laparoscopic versus open) and anesthesia (thoracic epidural versus general) techniques

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

TREATMENT

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients scheduled for colorectal cancer surgery

Exclusion criteria

* Emergent surgery * Intestinal obstruction * Contraindication for epidural catheter placement * Concomitant autoimmune disease * Concomitant infectious disease * Recent corticosteroids or anti-inflammatory medications

Design outcomes

Primary

Measure	Time frame	Description
Plasma levels of several cytokines after colorectal cancer surgery	within the first two days after surgery	We have measured and compared perioperative plasma levels of interleukin-1, interleukin-2, interleukin-6,monocyte chemotactic protein-1, interleukin-8, nitric oxide, C-reactive protein and procalcitonin in our three-group sample.

Secondary

Measure	Time frame	Description
Incidence of adverse clinical outcomes between groups	within 30 days after surgery	We have analyzed if there is any significant difference on respiratory, cardiac, renal or infectious postoperative complications between groups

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026