Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01427621

Enrollment

Registered

2011-09-01

Start date

2010-03-31

Completion date

2011-05-31

Last updated

2011-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Valve Diseases

Brief summary

Pulmonary dysfunction after cardiac surgery with CPB remains to be a problem complicating the postoperative course of the patients. The investigators hypothesized that RIPCcom, combined intervention of remote ischemic preconditioning and remote ischemic postconditioning, would confer beneficial influence on inflammatory response and resultant postoperative pulmonary dysfunction after CPB in patients undergoing complex valvular heart surgery who are at increased risk of postoperative pulmonary dysfunction.The aim of this study was to evaluate the lung-protective effect of combined remote ischemic pre- and post-conditioning in patients undergoing complex valvular heart surgery.

Interventions

PROCEDUREremote ischemic pre and postconditioning (RIPC)

RIPCcom group: combined intervention of remote ischemic pre- and postconditioning consisted of three 10-minute cycles of right lower limb ischemia, which was induced with an automated cuff-inflator placed on the right upper leg and inflated to 250 mmHg, with an intervening 10 minute of reperfusion during which the cuff was deflated. This intervention were performed at 10 minutes after induction of anesthesia and then 10 min after weaning from CPB.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

* patients undergoing valvular heart surgery. * Age: 20\ 80.

Exclusion criteria

* Emergency operation. * patients with peripheral vascular disease. * Patients with a known history or clinical evidence of chronic obstructive pulmonary disease. * Patients with hepatic or renal dysfunction * Patients with acute myocardial infarction within 1 week before surgery

Design outcomes

Primary

Measure	Time frame	Description
Comparison of postoperative PaO2/FiO2	at 10 minutes after anesthetic induction	Comparison of postoperative PaO2/FiO2 between RIPCcom group and Control group.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026