Attention, Cognition, Memory, Mental Health
Conditions
Keywords
Cognitive performance, Attention, Memory, Glucose, Sacharose, Elderly, Memory complaints
Brief summary
The objective of the current study is to determine the acute effect of a glucose drink and a sacharose drink compared to a placebo on cognitive performance in elderly with light memory complaints. The investigators expect that the sugar containing drinks will improve memory and attentional functions. Furthermore, blood glucose response will be measured.
Interventions
DIETARY_SUPPLEMENTglucose
The effect of a glucose solution on cognitive performance will be measured.
DIETARY_SUPPLEMENTsacharose
The effect of a sacharose solution on cognitive performance will be measured.
DIETARY_SUPPLEMENTPlacebo
The effect of a placebo drink with sweeteners on cognitive performance will be measured.
Sponsors
Suikerstichting Nederland (Baarn)
Wageningen University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Men and women * 70 years and older * Memory complaints
Exclusion criteria
* Type I or II diabetes * Parkinson disease * MMSE \< 25 (to exclude cognitively impaired subjects * CES-D \> 16 (to exclude depressive subjects) * Pharmacological antidepressives or medication for dementia * Liver disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Performance on the paired associate recall test | cognitive tests will start 15 minutes after ingestion of the intervention product | Cognitive performance will be assessed by several sensitive tests. Power is calculated on the paired associate recall test, but also several other cognitive performance test focusing on memory, attention and reaction time will be performed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mood | within 15 minutes after consuming the test drink and after completing the cognitive tests (within 90 minutes after consuming the test drink) | Mood will be measured by the POMS, after consuming the test drink, and after completing the congitive tests. |
| Blood glucose response | from baseline till 90 minutes after consuming the drink | Blood glucose will be measured at five time points, at t=0, after 15 minutes, 30, 60 and 90 minutes. |
| Plasma insulin levels | At t= -15 minutes, before consuming the test drink | One venapunction will be carried out at baseline to measure plasma insulin levels. |
Countries
Netherlands
Outcome results
None listed