Schizophrenia
Conditions
Keywords
rTMS-induced cumulative pattern of sBDNF
Brief summary
This study aims at investigating the neuroplastic potential and the possible factors affecting rehabilitation in chronic schizophrenia patients on stable medication, by investigating the cumulative pattern of serum BDNF representing the neuroplasticity in the brain, through quantitative stimulus such as rTMS.
Detailed description
Subjects who have been enrolled for this study will take baseline evaluation for sociodemographic data and serum level of BDNF, plasma Prolaction, and magnesium, etc. And then, weekday regular stimulation through rTMS will be applied on DLPFC of brain. After the completion of stimulation for 2 weeks, the change or response of serum BDNF will be analyzed and compared.
Interventions
DEVICECR Technology, TAMAS for repetitive TMS
repetitive TMS, lef DLPFC, 20Hz, 100% of MEP, 2weeks
Sponsors
Jeonbuk Provincial Maeumsarang Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* duration of illness over 10 years * on stable medication, antipsychotics * no change on medication within at least 2 weeks * Diagnosis of Schizophrenia according to DSM-IV-TR
Exclusion criteria
* left or both-handedness * anticonvulsant use * lorazepam equivalent over 3 mg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change from baseline of serum BDNF concentration | baseline-1 week-2 week-4 week |
Countries
South Korea
Outcome results
None listed