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Doppler Sonography, MR Venography, Plethysmography for the Diagnosis of CCSVI

Doppler Sonography, Magnetic Resonance Venography, Air-plethysmography in the Non-invasive Diagnostics of Chronic Cerebrospinal Venous Insufficiency (CCSVI)

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01425554
Enrollment
126
Registered
2011-08-30
Start date
2011-08-31
Completion date
2013-12-31
Last updated
2015-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Cerebrospinal Venous Insufficiency

Keywords

Vascular malformations in the internal jugular veins

Brief summary

This study is aimed at evaluation of diagnostic value of Doppler sonography, MR venography and air-plethysmography for the assessment of abnormalities in the internal jugular veins, with catheter venography as the reference test.

Interventions

OTHERDoppler sonography of internal jugular veins

Doppler sonography of internal jugular veins

OTHERMagnetic resonance venography of internal jugular veins

Magnetic resonance venography of internal jugular veins

OTHERAir-plethysmography of the neck

Air-plethysmography of the neck

OTHERCatheter venography of internal jugular veins

Catheter venography of internal jugular veins

Sponsors

Euromedic Specialist Clinics, Poland
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes

Inclusion criteria

1. Patients group Inclusion Criteria: * confirmed diagnosis of multiple sclerosis

Exclusion criteria

* coexisting another neurologic pathology (e.g. stroke, Parkinson disease) * significant stenosis of carotid or vertebral arteries * other significant abnormalities of blood vessels of the upper part of the body * tricuspid valve incompetence * allergy to iodine contrast dye * chronic renal failure * pregnancy * other severe comorbidities or significant abnormalities in standard lab tests 2. Healthy volunteers. Inclusion Criteria: * none

Design outcomes

Primary

MeasureTime frameDescription
Positive and negative predictive value of Doppler sonography, MR venography and air-plethysmographyAll non-invasive test are done up to 14 days prior to catheter venographyPositive and negative predictive value of Doppler sonography,MR venography and air-plethysmography for the detecting of vascular malformation in the internal jugular veins with catheter venography as the reference test

Countries

Poland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026