Hypertension, Left Ventricular Hypertrophy
Conditions
Keywords
hypertension, left ventricular hypertrophy, angiotensin receptor blocker, midwall mechanics, tissue Doppler imaging, Hypertension with left ventricular hypertrophy
Brief summary
The study hypothesis: Valsartan as an angiotensin II receptor blocker treatment has beneficial effects on both midwall mechanics and myocardial functions in hypertensive patients with Left ventricular hypertrophy.
Interventions
DRUGvalsartan
80/160 mg dosage of valsartan or 160+12,5 mg valsartan+hydrochlorothiazide combination, once a day, for six months
Sponsors
Novartis Pharmaceuticals
Mustafa Kemal University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* hypertension with left ventricular hypertrophy
Exclusion criteria
* clinical or laboratory evidence of secondary hypertension * heart failure * ischemic heart disease * valvular heart disease * arrhythmias * peripheral vascular disease * chronic obstructive pulmonary disease * neurologic disorders * diabetes mellitus * renal dysfunction * notable systemic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change from baseline in midwall fractional shortening (mFS) and tissue Doppler systolic wave (Sm) measured by echocardiography at six months | six months |
Secondary
| Measure | Time frame |
|---|---|
| change from baseline in systolic and diastolic blood pressure at six months | six months |
| change from baseline in left ventricular mass index measured by echocardiography at six months | six months |
Countries
Turkey (Türkiye)
Outcome results
None listed