The Impact of Surgical Treatment of Endometriomas on Ovarian Reserve

The Impact of Surgical Treatment of Ovarian Endometriomas on Ovarian Reserve: a Randomised Controlled Trial of Laparoscopic Ovarian Cystectomy Versus Cyst Ablation - a Pilot Study

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01425333

Enrollment

Registered

2011-08-30

Start date

2011-04-30

Completion date

2013-02-28

Last updated

2011-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometriosis

Keywords

Ovarian endometriomas, Laparoscopy, Cystectomy, Ablation

Brief summary

The aim of this study is to assess which of two commonly used surgical procedures in the treatment of ovarian cysts called endometriomas (cutting out of the cyst - cystectomy, or draining it and cauterising it's inner lining - ablation) causes the least damage to the ovary and is therefore best at maintaining the future fertility potential of a patient.

Interventions

PROCEDURESurgery for ovarian endometrioma

Patients undergoing surgery for ovarian endometrioma

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 42 Years

Healthy volunteers

Yes

Inclusion criteria

* Women undergoing laparoscopic surgery for treatment of unilateral endometriomas measuring ≥ 3cm and ≤ 8cm in diameter

Exclusion criteria

* Patients who have received oestrogen suppressing drugs (e.g. oral contraceptive pills, GnRHa) during the previous six months * Patients who have previously undergone surgical treatment of endometriomas * Patients with bilateral endometriomas * Patients with endometriomas of less than 3cm in size or more than 8cm in size * Pre-surgical evidence of reduced ovarian reserve * Pregnant patients * Patients unable to give informed consent e.g. patients with mental incapacity

Design outcomes

Primary

Measure	Time frame	Description
Anti-Mullerian Hormone (AMH)	6 months post-operatively	Change in anti-mullerian hormone level after surgery (at one week, three months and six months)

Secondary

Measure	Time frame	Description
Follicle Stimulating Hormone (FSH)	6 months	Change in follicle stimulating hormone levels after surgery (at one week, three months and six months)
Antral Follicle Count (AFC)	3 months	Change in AFC after surgery (at three months)

Countries

United Kingdom

Contacts

Primary ContactSaad Amer, MD, MRCOG

saad@amer@nottigham.ac.uk+44(1332)724612

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026