Psoriasis
Conditions
Keywords
psoriasis, systematic review, meta-analyses
Brief summary
This project involved a systematic literature review of published trials of treatments for moderate-to-severe plaque psoriasis. Data was extracted from the publications on various psoriasis endpoints including the Physician Global Assessment (PGA), Dermatology Life Quality Index (DLQI), and Short-Form 36 (SF-36). A traditional meta-analysis and a mixed treatment comparison was conducted on the extracted data.
Detailed description
This project involved a systematic literature review of published trials of treatments for moderate-to-severe plaque psoriasis. Data was extracted from the publications on various psoriasis endpoints including the Physician Global Assessment (PGA), Dermatology Life Quality Index (DLQI), and Short-Form 36 (SF-36). A traditional meta-analysis and a mixed treatment comparison was conducted on the extracted data. We included all published randomized controlled trials of treatments for moderate-to-severe psoriasis that met the study inclusion criteria.
Interventions
None listed
Sponsors
University of Connecticut School of Pharmacy and Hartford Hospital
Pfizer
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Randomized controlled clinical trials of treatments for moderate-to-severe plaque psoriasis. * Trials had to evaluate at least one of the following: Physician's Global Assessment (PGA), Dermatology Life Quality Index (DLQI) and/or the Short-Form 36 (SF-36).
Exclusion criteria
Observational studies * Trials that did not report the Physician's Global Assessment (PGA), * Dermatology Life Quality Index (DLQI) or the Short-Form 36 (SF-36).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physician Global Assessment (PGA) | — |
| Dermatology Life Quality Index (DLQI) | — |
| Short-Form 36 (SF-36) | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcomes | No secondary outcomes |
Outcome results
None listed