TLR-9 Antagonism in Steroid Resistant Optic Neuritis

Outcomes of TLR-9 Antagonism in Steroid Resistant Optic Neuritis; A Pilot Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01424735

Enrollment

Registered

2011-08-29

Start date

2006-07-31

Completion date

2010-05-31

Last updated

2011-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Optic Neuritis

Keywords

Best corrected Visual Acuity, Pupillary Reaction, Colour vision, Disc edema

Brief summary

Although idiopathic steroid resistant optic neuritis is very uncommon, there is no established treatment protocol for such patients. Toll like receptors (TLRs) especially TLR-9 has been shown to play a role in the pathogenesis of optic neuritis. This small case series aims to determine whether immunomodulators directed specifically at TLR-9(i.e. TLR-9 antagonism)play any role in improving the visual function in such patients.

Interventions

DRUGMycobacterium w.(Mw)-freeze dried extract 0.5ml

0.5 ml of Mw in 500ml 0.9% normal saline administered over two hours as an infusion. 2ml(4mg/ml) of dexamethasone administered two hours prior to Mw administration

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

Unilateral Steroid Resistant Optic Neuritis

Exclusion criteria

* bilateral optic neuritis * Associated Systemic disease * Prior treatment received

Design outcomes

Primary

Measure	Time frame
Improvement in all aspects of visual function	upto 6 months

Countries

India

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026